Zebra F Refill Ballpoint Pen for F-301, F-701, Expandz & Spiral. Pack of 12 Black

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Lambert DJ (1997). Freshwater Aquarium Fish. Edison, New Jersey: Chartwell Books. p. 19. ISBN 978-0-7858-0867-1. ZMotif SDK and programming documentation (job command information, coding sequence and sample code) and DLL libraries for:

Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N (September 2006). "Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene". EMBO Reports. 7 (9): 893–897. doi: 10.1038/sj.embor.7400757. PMC 1559663. PMID 16845369. In another study, an effort was made to therapeutically target the genetic program present in the tumor's origin neural crest cell using a chemical screening approach. [109] This revealed that an inhibition of the DHODH protein (by a small molecule called leflunomide) prevented development of the neural crest stem cells which ultimately give rise to melanoma via interference with the process of transcriptional elongation. Because this approach would aim to target the "identity" of the melanoma cell rather than a single genetic mutation, leflunomide may have utility in treating human melanoma. [110] Cardiovascular disease [ edit ] Major RJ, Poss KD (2007). "Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair". Drug Discovery Today: Disease Models. 4 (4): 219–225. doi: 10.1016/j.ddmod.2007.09.002. PMC 2597874. PMID 19081827.Because of its small size, however, it is very challenging to quantify the internal drug exposure. Traditionally multiple blood samples would be drawn to characterize the drug concentration profile over time, but this technique remains to be developed. To date, only a single pharmacokinetic model for paracetamol has been developed in zebrafish larvae. [104] Computational data analysis [ edit ] Machuca-Tzili LE, Buxton S, Thorpe A, Timson CM, Wigmore P, Luther PK, Brook JD (May 2011). "Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy". Disease Models & Mechanisms. 4 (3): 381–392. doi: 10.1242/dmm.004150. PMC 3097459. PMID 21303839. Plains zebra subspecies include the maneless zebra, grant’s zebra, crawshay’s zebra, chapman’s zebra, burchell’s zebra, and selous’ zebra, which have different geographical distributions. To encourage the fish to spawn, some researchers use a fish tank with a sliding bottom insert, which reduces the depth of the pool to simulate the shore of a river. Zebrafish spawn best in the morning due to their Circadian rhythms. Researchers have been able to collect 10,000 embryos in 10 minutes using this method. [24] In particular, one pair of adult fish is capable of laying 200–300 eggs in one morning in approximately 5 to 10 at time. [25] Male zebrafish are furthermore known to respond to more pronounced markings on females, i.e., "good stripes", but in a group, males will mate with whichever females they can find. What attracts females is not currently understood. The presence of plants, even plastic plants, also apparently encourages spawning. [24] Kimmel CB, Law RD (March 1985). "Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells". Developmental Biology. 108 (1): 78–85. doi: 10.1016/0012-1606(85)90010-7. PMID 3972182.

Mountain zebras are divided into two subspecies. Hartmann’s mountain zebra (Equus zebra zebra) and Cape mountain zebra (Equus zebra zebra) (Equus zebra hartmannae). Both prefer mountainous regions in Angola, Namibia, and South Africa. Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, etal. (August 2007). "MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics". Stem Cells. 25 (8): 2033–2043. doi: 10.1634/stemcells.2006-0724. PMID 17525239. Zebra’s Self-Service Center is your go-to spot for online tools, resources and support you need to get answers right away. Explore ways to get support to common device issues at a glance.Drummond IA (February 2005). "Kidney development and disease in the zebrafish". Journal of the American Society of Nephrology. 16 (2): 299–304. doi: 10.1681/ASN.2004090754. PMID 15647335. S2CID 25428361. Torraca V, Masud S, Spaink HP, Meijer AH (July 2014). "Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model". Disease Models & Mechanisms. 7 (7): 785–797. doi: 10.1242/dmm.015594. PMC 4073269. PMID 24973749. a b c Hill AJ, Teraoka H, Heideman W, Peterson RE (July 2005). "Zebrafish as a model vertebrate for investigating chemical toxicity". Toxicological Sciences. 86 (1): 6–19. doi: 10.1093/toxsci/kfi110. PMID 15703261. Zebrafish are hardy fish and considered good for beginner aquarists. Their enduring popularity can be attributed to their playful disposition, [28] as well as their rapid breeding, aesthetics, cheap price and broad availability. They also do well in schools or shoals of six or more, and interact well with other fish species in the aquarium. However, they are susceptible to Oodinium or velvet disease, microsporidia ( Pseudoloma neurophilia), and Mycobacterium species. Given the opportunity, adults eat hatchlings, which may be protected by separating the two groups with a net, breeding box or separate tank. Liu S, Leach SD (2011). "Zebrafish models for cancer". Annual Review of Pathology. 6: 71–93. doi: 10.1146/annurev-pathol-011110-130330. PMID 21261518.

Kizil C (January 2018). "Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain". Current Pathobiology Reports. 6 (1): 71–77. doi: 10.1007/s40139-018-0158-x. PMC 5978899. PMID 29938129. Rosen JN, Sweeney MF, Mably JD (March 2009). "Microinjection of zebrafish embryos to analyze gene function". Journal of Visualized Experiments (25). doi: 10.3791/1115. PMC 2762901. PMID 19274045. Product level: Essentials. Rev-2019-1, P1108968-EN. This ZebraDesigner Essentials Version 3 manual covers Typographical Conventions, Activating ZebraDesigner, and more.Meeker ND, Trede NS (2008). "Immunology and zebrafish: spawning new models of human disease". Developmental and Comparative Immunology. 32 (7): 745–757. doi: 10.1016/j.dci.2007.11.011. PMID 18222541. D. rerio is a common and useful scientific model organism for studies of vertebrate development and gene function. Its use as a laboratory animal was pioneered by the American molecular biologist George Streisinger and his colleagues at the University of Oregon in the 1970s and 1980s; Streisinger's zebrafish clones were among the earliest successful vertebrate clones created. [33] Its importance has been consolidated by successful large-scale forward genetic screens (commonly referred to as the Tübingen/Boston screens). The fish has a dedicated online database of genetic, genomic, and developmental information, the Zebrafish Information Network (ZFIN). The Zebrafish International Resource Center (ZIRC) is a genetic resource repository with 29,250 alleles available for distribution to the research community. D. rerio is also one of the few fish species to have been sent into space. Rennekamp AJ, Peterson RT (February 2015). "15 years of zebrafish chemical screening". Current Opinion in Chemical Biology. 24: 58–70. doi: 10.1016/j.cbpa.2014.10.025. PMC 4339096. PMID 25461724. a b Llewellyn, Martin S.; Boutin, Sébastien; Hoseinifar, Seyed Hossein; Derome, Nicolas (2014-06-02). "Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries". Frontiers in Microbiology. Frontiers. 5: 207. doi: 10.3389/fmicb.2014.00207. ISSN 1664-302X. PMC 4040438. PMID 24917852. S2CID 13050990. Cho SJ, Park E, Baker A, Reid AY (2020-09-10). "Age Bias in Zebrafish Models of Epilepsy: What Can We Learn From Old Fish?". Frontiers in Cell and Developmental Biology. 8: 573303. doi: 10.3389/fcell.2020.573303. PMC 7511771. PMID 33015065.