Activon Medical Grade Manuka Honey 25g (Pack of 3)

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There will be high levels of exudate, but this is perfectly normal. It will decrease over time, therefore your secondary dressing of choice may initially need to be super absorbent. For this, the producer of Activon recommends using Eclypse – Super Absorber Dressings. Other researchers support the occurrence of enhanced effects of honey and antibiotics. Klein et al (2020) 31 used a broth culture assay to investigate the ability of subinhibitory concentrations of a range of medical grade honeys (Comvita ® Manuka Medihoney ®; Comvita ® Medihoney ® Antibacterial Wound Gel™; Revamil ® gel; and Surgihoney™RO ®) to enhance the activity of antibiotics (tetracycline, sulphatriad, streptomycin, penicillin G, chloramphenicol and ampicillin) against S. aureus and P. aeruginosa. In their study, bacteria were incubated aerobically overnight in broth cultures containing 10% honey. Samples from these cultures were then spread onto TSA plates and antibiotic discs (Mastring-S, Mast Group Ltd) were added to the agar and incubated at 37°C. The researchers found that the ability of the honeys to enhance the activity of the antibiotic depended on the type of honey, the antibiotic, and the bacterial species. Their key findings were that Surgihoney™RO ® and Comvita ® Medihoney ® Antibacterial Wound Gel™ increased the activity of tetracycline and ampicillin against S. aureus and increased the activity of tetracycline against P. aeruginosa. It’s medical grade honey, especially produced for application on wounds. It has unique properties and is produced in the medical Manuka honey program NZ. Activon Tube contains 100% Manuka honey with no additives from New Zealand.

If the area of the wound is showing the classical signs of inflammation: redness, pus, swelling and pain. Zone of inhibition induced by the herbal gel formulation was greater than honey alone (35.1 mm vs 13.1 mm respectively). When first applied, you may feel a discomfort and may need to take an analgesic. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. Are these products complying with the regulations? Discomfort can be experienced when honey is applied, depending on sensitivity of the wound it may be necessary to consider an appropriate level of analgesia. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. How to UseAlthough the honey is not absorbed into the blood stream, we advise monitoring the levels of patients with diabetes.

Honey and ginger combination induced higher mean zones of inhibition than honey or ginger alone or standard antibiotic discs (methicillin, penicillin, amoxicillin). Synergistic antimicrobial activity of Medihoney and rifampicin combination against MRSA and clinical isolates of S. aureus.

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Hydrogen peroxide activity. Honey contains an enzyme called oxidase. Its role is to break the glucose down into gluconic acid and hydrogen peroxide. Due to low pH, this doesn’t happen in pure honey, but when it is applied on a wound, the serum from the tissues dilute the honey and raises its pH, also adding sodium and activating the oxidase. Small quantities of hydrogen peroxide is produced little by little directly on the wound.

Synergistic effects of sub-inhibitory concentrations (<8% w/v) of manuka honey (Comvita, Ltd) and rifampicin on S. aureus biofilm formation and on established biofilms have also been observed in vitro. 24 , 30 Interestingly, some antibiotic combinations (clindamycin, gentamicin and oxacillin) showed an antagonistic effect on S. aureus established biofilms when the honey was used at sub-inhibitory concentrations but not at higher honey concentrations above the MIC (eg, 16% w/v). Physiological and metabolic differences in bacteria within a biofilm could impair the ability of sub-inhibitory concentrations of honey in combination with antibiotics to kill the bacteria. Kwakman et al (2011) 52 investigated the antimicrobial effects of supplementing Revamil honey with the antimicrobial peptides LL-37 and the synthetic peptide bacterial peptide 2 (BP2). They reported that the antimicrobial activity of LL-37 was inhibited in the presence of honey, but this was not the case for BP2. Using a liquid bactericidal assay, it was shown that Revamil honey supplemented with 75µM BP2 had more rapid antibacterial activity against MRSA and extended spectrum β lactamase (ESBL) E. coli and had a broader spectrum of antibacterial activity than Revamil alone. The authors considered supplementing the honey with hydrogen peroxide or MGO but were concerned that high levels of these components may not be biocompatible. Long-Lasting: Presented in a convenient 25g tube, Activon Tube remains effective for 90 days once opened.Other therapeutic agents being considered for use in combination with honey for the treatment of wounds include honey and bacteriophage therapy, honey supplemented with antimicrobial peptides, honey combined with cyclodextrins or hydrogel, or honey and laser therapy. Novel approaches to wound healing have involved adding a combination of antimicrobial agents to nanofibrous scaffolds. For example, Sarhan and Azzazy (2017) 50 reported that honey (Egyptian clover) (30%) chitosan nanofibers loaded with bee venom (0.01%) and bacteriophages had superior antimicrobial activity in a broth culture assay against MDR P. aeruginosa in comparison to ionic silver containing Aquacel-Ag wound dressing. Furthermore, the novel honey bacteriophage dressing demonstrated better wound healing ability in mice when compared to Aquacel-Ag wound dressing. Oliveira et al (2017) 51 also reported synergistic antimicrobial effects against E. coli biofilms formed on 96 well plates at 12 and 24 hours using multi-floral Portuguese honey and an E. coli specific bacteriophage. This approach combines the antibiofilm effects of honey with the ability of bacteriophages to lyse bacteria. Scanning electron microscopy revealed that honey caused perturbations in the membrane of the E. coli whilst the bacteriophage caused complete lysis with only vesicle structures left behind. L-Mesitran demonstrated antifungal activity against C. albicans (MIC 25%–50%), whereas 40% Mexican yucatan honey did not. Rifampicin and manuka honey considered to be most effective as demonstrated synergistic antimicrobial activity against all tested strains including planktonic bacteria and S. aureus biofilm formation. Simple manuka and kanuka are also very good on any type of skin infection, in Australia being widely use in treating infected wounds in animals.

Surgihoney™RO ® and Comvita ®Medihoney ® Antibacterial Wound Gel™ increased the sensitivity of S. aureus to tetracycline and ampicillin. In vitro research has also examined the antimicrobial effects of combining honey and other natural agents such as ginger, royal jelly, propolis and vitamins. Ewnetu et al (2014) 36 reported that mixtures of Ethiopian honey and ginger extracts (50% v/v) had superior antimicrobial activity than ginger extract (50% v/v) or honey alone (50% v/v) in a well diffusion assay against E. coli, Staphylococcus aureus (MRSA), and antibiotic-resistant strains of E. coli and K. pneumoniae. Reportedly, the honey and ginger extract combination induced larger zones of inhibition than standard antibiotic discs. Boukraa (2008) 37 described enhanced effects of subinhibitory concentrations of Algerian honeys (orange blossom and eucalyptus) when combined with royal jelly against P. aeruginosa. For example, when compared with the MIC of honey alone there was a considerable decrease (~90%) in the MIC when honey (1% v/v) was combined with 3% royal jelly. Al-Waili et al (2012) 38 using broth macro-dilution reported synergistic effects of subinhibitory concentrations of sumra honey from Saudi Arabia when combined with subinhibitory concentrations of propolis against S. aureus, E. coli C. albicans and mixed microbial cultures. The MICs of honey and propolis combinations were lower than honey and propolis alone against all micro-organisms tested in the study. Propolis obtained from Saudi Arabia demonstrated superior synergistic effects in comparison to propolis obtained from Egypt suggesting that the type of propolis is important. In a short communication by Kowalski and Makarewicz (2017) 39 honey supplemented with 1% propolis demonstrated higher antibacterial activity than honey alone against E. coli in a well diffusion assay. Similarly, Oses et al (2016) 40 reported synergistic antimicrobial effects of honeys from Spain against E. coli, S. aureus and P. aeruginosa in a disc diffusion assay when ethanol extracts of propolis (0.1%, 0.3% or 0.5%) were added to the undiluted honey. Furthermore, the anti-inflammatory effects of the honey (75%), measured using a hyaluronidase inhibition assay, were enhanced when propolis ethanol extracts were added. Honey has also been combined with other natural agents including cinnamaldehyde found in cinnamon and carvacrol, a monoterpene found in thyme. The combination of honey obtained from Damavand district Iran, with sub-MIC concentrations of cinnamaldehyde and carvacrol had greater antibacterial activity than honey alone against suspensions of clinical isolates of P. aeruginosa. 41 This triple combination was also reported to reduce the expression of exoS gene involved in P. aeruginosa virulence and ampC gene involved in P. aeruginosa resistance to antibiotics such as carbapenems and monobactams. Even more complex mixtures of natural agents have been tested. For example, Dashtdar et al 2016 42 prepared a gel composed of herbal extracts of Acacia catechu, Castanea sativa, Ephedra sinica and Momia combined with honey (25%), maple saps, Phoenix dactylifera (date), pomegranate extract and Azadirachta indica gum. This gel had a higher antibacterial activity in an agar well diffusion assay than the antibiotic cloxacillin or honey alone against P. aeruginosa. Natural bioactive agents such as vitamins have also been combined with honey and antimicrobial activity assessed. Majtan et al (2020) 43 investigated the antimicrobial activity of Slovakian honeys and a commercially available UMF 15+ manuka honey (Natures Nectar, UK) supplemented with sub-MIC concentrations of vitamin C in an MIC assay against bacterial isolates including P. aeruginosa and S. aureus. The antimicrobial activity of honey vitamin C combination was also assessed against P. aeruginosa, S. aureus, S. agalactiae and E. faecalis multi-species biofilms. Their key findings were that supplementation of honey with sub-MIC concentrations of vitamin C reduced the MIC of all types of honey against planktonic preparations of P. aeruginosa. In contrast, supplementation of honeydew honey with sub-MIC concentrations of vitamin C increased the MIC against planktonic S. aureus. Honeydew honey (100%) supplemented with vitamin C (100mg/g of honey) had superior antibiofilm activity than honey alone and caused clearance of all the bacterial species within the biofilm after 48 hours. Vitamin C is reported to have antibacterial activity and the authors suggested that the antibacterial effects of honey and vitamin C combination may be due to increased production of reactive oxygen species in bacterial cells. In another study, L-Mesitran, a medical honey formulation containing 40% Mexican yucatan honey and vitamins C and E was reported to have anti-fungal activity against Candida albicans whilst 40% Mexican yucatan honey alone did not. 44 The authors suggested that the vitamins or other components in the L-Mesitran formulation may be enhancing the antifungal activity of the honey. Furthermore, L-Mesitran formulation was found to have superior antimicrobial activity against Staphylococcus pseudintermedius, a cause of canine pyoderma, and Malassezia pachydermatis in comparison to the honey component of L-Mesitran only. 45 The authors again concluded that other components in the L-Mesitran formulation which include medical grade hypoallergenic lanolin, propylene glycol, polyethylene glycol 4000 and vitamins C and E may be enhancing the antimicrobial activity of the honey.

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Supplementation of honey with vitamin C reduced the MIC of all honey types tested against planktonic P. aeruginosa. Supplementation of honeydew honey with vitamin C increased the MIC against planktonic S. aureus. If you need recurring bulk supply for a business, restaurant, or retail store, we can set you up with a business account. This provides benefits like discounted pricing, dedicated account management, and tailored delivery options. For each honey type there was > 90% decrease in the MIC when 3% (v/v) royal jelly was added; a 66.6% decrease when 2% (v/v) royal jelly was added and a 50% decrease in MIC when 1% (v/v) royal jelly was added. Comvita ®Medihoney ® Antibacterial Wound Gel™, Comvita ® Manuka Medihoney ® and Surgihoney™RO ® enhanced the sensitivity of P. aeruginosa to tetracycline.