Vitamin B3 Nicotinamide (Niacinamide) 500mg 180 Capsules (V) Vegan. No-Flush Niacinamide. Made in The UK by Health4All

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Rottembourg JB, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. Kidney Int. 2005;68(6):2911-2. View abstract. Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. Jan 2006;77(1 Suppl):11-16. Ketteler M, Wiecek A, Rosenkranz AR, et al. Modified-release nicotinamide for the treatment of hyperphosphataemia in haemodialysis patients: 52-week efficacy and safety results of the phase III randomised controlled NOPHOS trial. Nephrol Dial Transplant 2022. View abstract.

Nicotinamide | Memorial Sloan Kettering Cancer Center Nicotinamide | Memorial Sloan Kettering Cancer Center

Chronic kidney disease is the progressive loss of kidney function that affects your body’s ability to clean and filter blood and control blood pressure. Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, Marres HA, de Bree R, van der Kogel AJ, Hoogsteen IJ, Bussink J, Span PN, Kaanders JH. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial. J Clin Oncol. 2012 May 20;30(15):1777-83. View abstract. Kamal M, Abbasy AJ, Muslemani AA, Bener A. Effect of nicotinamide on newly diagnosed type 1 diabetic children. Acta Pharmacol Sin. 2006;27(6):724-7. View abstract. Cabrera-Rode E, Molina G, Arranz C, Vera M, et al. Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes. Autoimmunity. 2006;39(4):333-40. View abstract.NAM administration-induced elevation of NAD + level supports renal and fecal Pi excretion and alleviates hyperphosphatemia, which is frequently associated with end-phase renal insufficiency [ 87]. NAD + inhibits Na+-phosphate cotransporters (NaPi2a and NaPi2b), major routes for phosphate uptake in renal proximal tubule and intestine [ 88, 89]. Rolfe HM. A review of nicotinamide: treatment of skin diseases and potential side effects. J Cosmet Dermatol. Dec 2014;13(4):324-328. Hui F, Tang J, Williams PA, et al. Improvement in inner retinal function in glaucoma with nicotinamide (Vitamin b3) supplementation: A crossover randomized clinical trial. Clin Exp Ophthalmol. 2020;48(7):903-914. doi:10.1111/ceo.13818.

British Association of Dermatologists

Kim B, Halliday GM, Damian DL. Oral nicotinamide and actinic keratosis: a supplement success story. Curr Probl Dermatol 2015; 46: 143–9. DOI: 10.1159/000366550. PubMed Olmos PR, Hodgson MI, Maiz A, et al. Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics. Diabetes Res Clin Pract. 2006;71(3):320-33. View abstract.Children: Niacinamide is likely safe when taken by mouth in the recommended amounts by age. Children should avoid taking niacinamide doses above the daily upper limits, which are 10 mg for children 1-3 years of age, 15 mg for children 4-8 years of age, 20 mg for children 9-13 years of age, and 30 mg for children 14-18 years of age. Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999. Melasma: A skin condition that causes hyperpigmentation, or dark spots, melasma often occurs on unprotected skin regularly exposed to the sun. According to a study, topical (skin) niacinamide cream reduced the appearance of dark spots in people with melasma.

Nicotinamide: Benefits, Uses, Side Effects - Health

Thompson BC, Halliday GM, Damian DL. Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin. PLoS One. 2015;10(2):e0117491. Zhang Y, Ma T, Zhang P. Efficacy and safety of nicotinamide on phosphorus metabolism in hemodialysis patients: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(41):e12731. doi:10.1097/MD.0000000000012731 Nicotinamide has anti-inflammatory properties, which may be used for the treatment of bullous (blistering) diseases. Ratnarajah K, Zargham H, Jafarian F. Confusion among different forms of vitamin B3. J Cutan Med Surg. 2020;24(6):642-643. doi:10.1177/1203475420936649 Shalita AR, Smith JG, Parish LC, et al. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol 1995;34:434-7. View abstract.

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Nicotinamide has established medical uses to treat conditions stemming from niacin deficiency such as pellagra. Oral and topical formulations are used to treat a variety of inflammatory skin conditions including acne vulgaris and rosacea (1) (24) (2), hyperpigmentation (25) and to prevent hair thinning (26).