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Be aware of:Supplements containing ALA (another omega-3 fatty acid) instead of DHA/EPA. ALA is found mainly in plant oils such as flaxseed, and only very small amounts are converted by the body to useful EPA and then to DHA. Practically, this means DHA/EPA needs to be consumed directly from food or supplements. Note that studies of health benefits of omega-3 generally involve using DHA/EPA omega-3 supplements (not ALA omega-3). While it is important to eat a wide range of foods, the vegetables that have the highest amount of lutein are: The recommended dietary allowance (RDA) of vitamin E for adults over 14 years old is 22.4 IU; but it is not the maximum dose. Rather, it is the dose that nutrition experts have decided is sufficient for most people to remain healthy. The AREDS formula contains 400 IU to provide vitamin E beyond usual dietary intake. New blood vessel growth is medically known as “neovascularisation”. Neovascularisation can cause a lot of damage to your macula and can eventually lead to scarring. Both the new blood vessels and the scarring cause damage to your central vision and may lead to a blank patch in the centre of your sight.
A supplement containing DHA/EPA omega-3 should also been considered – especially since taking 250mg DHA ‘contributes to the maintenance of normal vision’ and is an authorised EU health claim! Mares-Perlman JA, Fisher AI, et al. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. 2001 Mar 1;153(5):424-32. doi: 10.1093/aje/153.5.424. https://pubmed.ncbi.nlm.nih.gov/11226974/ The trial found that people who took specific supplements were 25% less likely to progress to advanced AMD over the five-year study period.
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Dunaief J. Lutein and zeaxanthin for protection against macular degeneration. Bright Focus Foundation. Your optometrist or ophthalmologist might say you have early AMD if you have larger drusen in one or both your eyes. Other changes at the macula, as well as drusen, will indicate whether your early AMD has a low, medium, or high risk of progression (worsening). This specific nutrient combination has been formulated to match the supplements used in Phase 2 of the Age Related Eye Disease Study (AREDS2). The AREDS studies are large, scientific trials conducted by the National Eye Institute in the United States, which looked at the role of dietary supplements in Age Related Macular Degeneration. TRUST AND BENEFIT FROM THE SPECIALISTS - The trusted Vision Defender range of eye health supplements has been specially developed by qualified health care professionals to improve the health and vision of your eyes. Our Chief Pharmacist and Co-Founder Keith specialises in eye nutrition and has written a book: “Help! What Vitamins Should I Take for My Eyes?”. Our eyesight is precious and important in everything we do - continue to do all the things you love with Vision Defender. National Center for Biotechnology Information (NCBI). Age-related macular degeneration (AMD): Overview.
The AREDS2 formula has largely superseded the original AREDS formula, and remains the ‘Gold Standard’ in nutritional supplementation in AMD. Eye-healthy foods. Studies show that nutritional supplements alone are not enough to prevent or delay advanced AMD. You also should eat a healthy, balanced diet. This includes dark leafy greens (like spinach and kale) along with yellow, orange and other colorful fruits and vegetables. Eating fatty fish like salmon may also lower your risk of early or advanced AMD. While we believe that taking supplements containing lutein may be beneficial to eye health, we do not endorse any brand. Smoking Eye Disease Case-Control Study Group. Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol. 1993 Jan;111(1):104-9. doi: 10.1001/archopht.1993.01090010108035. https://pubmed.ncbi.nlm.nih.gov/7678730/This means that at present these supplements cannot be clearly recommended to everyone with AMD. More research is needed to determine if antioxidant and other supplements marketed for AMD are worth taking. Talk to your GP before taking supplements or making major changes to your diet, especially if you take other medications. People who take warfarin, for example, may need to avoid high doses of omega-3 as it thins the blood. Vitamins E and K may also interact with medicines like warfarin and aspirin. However, data from other studies on the relationship between vitamin E and prostate cancer conflict: mg copper as cupric oxide (added because high levels of zinc can reduce the amount of copper in the body). AREDS 2 (Age-Related Eye Disease Study 2) was a very large research study. It looked at taking vitamins and minerals daily for AMD. This study found that certain nutritional supplements could help some people who have a lot of drusen. These supplements may also lower risk of wet AMD and vision loss in the second eye of people who lost vision in one eye from AMD. Taking the following nutritional supplements every day may help these people lower their risk of getting late-stage or wet AMD:
Two large studies, Age-Related Eye Disease Study AREDS1 and AREDS2, suggested that certain nutritional supplements can slow down the progression of AMD by about 25%. AREDS2 in 2013 tested a modified version of the AREDS1 formula. Lutein and zeaxanthin are yellow plant pigments which give certain foods their colour. Lutein and zeaxanthin are found in high concentrations in the macula. Another carotenoid, meso-zeaxanthin, is formed in the body from lutein.
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Based on the results of AREDS and AREDS2 and concerns about the risk of beta-carotene for smokers, the current recommended daily formula to slow down the progression of AMD in people already diagnosed is:
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