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Rosenblatt, A.; Stamford, T.C.M.; Niederman, R. (2009). "Silver diamine fluoride: a caries "silver-fluoride bullet" ". Journal of Dental Research. 88 (2): 116–25. doi: 10.1177/0022034508329406. PMID 19278981. S2CID 30730306.

The primary outcome will be the assessment of NAFLD resolution, or change in its grade, as assessed by the difference in the attenuation coefficient between liver and spleen, obtained by CT of the upper abdomen, at the end (after) compared to beginning (before) the trial. In summary, the primary outcome is to investigate whether silymarin supplementation can reduce liver fat content in NAFLD patients, measured by a CT scan. Secondary outcomes a b "The origins of coinage". britishmuseum.org. Archived from the original on 2 May 2019 . Retrieved 21 September 2015. Most silver compounds have significant covalent character due to the small size and high first ionization energy (730.8kJ/mol) of silver. [11] Furthermore, silver's Pauling electronegativity of 1.93 is higher than that of lead (1.87), and its electron affinity of 125.6kJ/mol is much higher than that of hydrogen (72.8kJ/mol) and not much less than that of oxygen (141.0kJ/mol). [30] Due to its full d-subshell, silver in its main +1 oxidation state exhibits relatively few properties of the transition metals proper from groups 4 to 10, forming rather unstable organometallic compounds, forming linear complexes showing very low coordination numbers like 2, and forming an amphoteric oxide [31] as well as Zintl phases like the post-transition metals. [32] Unlike the preceding transition metals, the +1 oxidation state of silver is stable even in the absence of π-acceptor ligands. [29] Patients will provide informed consent themselves. All eligible participants have received information about the study and had the opportunity to have their questions answered to their satisfaction. The blinded evaluator has obtained written informed consent (IC) from all participants prior to assessment. Additional consent provisions for collection and use of participant data and biological specimens {26b} See also: Silver plating, Silvering, and Silver-gilt Embossed silver sarcophagus of Saint Stanislaus in the Wawel Cathedral was created in main centers of the 17th century European silversmithery – Augsburg and Gdańsk [106] 17th century silverwareMicrocrystalline cellulose, corn starch, and colloidal silicon dioxide were used as standard excipients in all capsules of both I and C. The capsule composition did not include dyes, preservatives or additives in I or C, guaranteeing the standardization of their appearance. The capsule weight, size, shape, and coating were identical between I and C, and have been designed to ensure the same ease of swallowing, to minimize risks of gastric discomfort for the participants, and to ensure similar disintegration time and propensity for swelling. The capsules are visually unidentifiable between I and C. All I and C capsules were manufactured and kindly donated by Singular Pharma (Salvador, Brazil). The expiry date is three months after production. Criteria for discontinuing or modifying allocated interventions {11b} There will be no data monitoring committee since only the primary evaluator, the research team, and the coordinator assistant will have access to the clinical trial data. Additionally, this trial is a low-risk intervention, and participants are advised to report any unexpected or adverse effects to the research team. Adverse event reporting and harms {22}

Participants are randomized to groups intervention (I) or control (C). They receive identical capsules and follow the trial instructions for 12 weeks. All participants are instructed to take two capsules per day soon after a meal. Considering the pathophysiology of NAFLD and pharmacotherapies currently available for its treatment or management, there are no specific pharmacological agents currently approved for NAFLD specifically that could be compared to the test item. Therefore, the research team adopted a methodological design using a placebo. Intervention description {11a} Ratte, Hans Toni (1999). "Bioaccumulation and toxicity of silver compounds: A review". Environmental Toxicology and Chemistry. 18 (1): 89–108. doi: 10.1002/etc.5620180112. S2CID 129765758.I participants receive 700 mg silymarin + 8 mg vitamin E + 50 mg phosphatidylcholine, daily. C participants receive 700 mg maltodextrin + 8 mg vitamin E + 50 mg phosphatidylcholine, daily. The sample size was determined through an accuracy analysis of the primary outcome. A significance level of 0.05 and a power of 80% were adopted, which resulted in a minimum sample size of approximately 132 participants. Recruitment {15} Most other binary alloys are of little use: for example, silver–gold alloys are too soft and silver– cadmium alloys too toxic. Ternary alloys have much greater importance: dental amalgams are usually silver–tin–mercury alloys, silver–copper–gold alloys are very important in jewellery (usually on the gold-rich side) and have a vast range of hardnesses and colours, silver–copper–zinc alloys are useful as low-melting brazing alloys, and silver–cadmium– indium (involving three adjacent elements on the periodic table) is useful in nuclear reactors because of its high thermal neutron capture cross-section, good conduction of heat, mechanical stability, and resistance to corrosion in hot water. [53] Etymology