Medipet Dog Fresh Breath Foaming Mousse 150ml

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As with all inhaled corticosteroids, special care is necessary in patients with active or quiescent pulmonary tuberculosis.

As your cat grows through kitten stages and into adulthood, their health needs change and develop. Staying on top of vaccinations, flea and worm treatments is made easier with the Medivet Healthcare Plan. Key Features

There are limited data in pregnant women. Administration of fluticasone propionate during pregnancy should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. It is important, that the dose of inhaled corticosteroid is titrated to the lowest dose at which effective control is maintained. Treatment with fluticasone propionate should not be stopped abruptly.

There are no data on human fertility. Animal studies indicate no effects of fluticasone propionate on male or female fertility. Subcutaneous embryofetal development studies in mouse and rat at 45 and 100 mcg/kg, respectively (approximately equivalent to 4 and 6 times the maximum recommended daily inhaled dose of 500 mcg twice daily in adults based on mouse and rat plasma levels of 486 and 710 pg/mL, respectively) resulted in fetal developmental toxicity characteristic of a potent corticosteroid, including cleft palate and embryonic fetal growth retardation, at doses that caused maternal toxicity. The no effect level for these finding in rat were associated with systemic exposures approximately 3 times the highest clinical exposure based on rat plasma level of 310 pg/mL. In the rabbit, fetal weight reduction and cleft palate occurred at a maternally toxic subcutaneous dose of 4 mcg/kg (less than 1.4 times the maximum recommended inhaled dose of 500 mcg twice daily based on rabbit plasma level of 149 pg/mL). However, fluticasone propionate administered via inhalation to rats did not induce teratogenicity at maternal toxic doses associated with exposures 17 times the human exposure achieved with the maximum recommended daily inhaled dose based on rat plasma level of 1890 pg/mL. Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, decreased bone mineral density, cataract, glaucoma

No evidence of impairment of fertility occurred in fertility studies in male and female rats at subcutaneous doses of fluticasone propionate up to 50 mcg/kg/day (approximately 6 times the human exposure associated with the maximum recommended daily inhaled dose of 500 mcg twice daily (110 pg/mL), based on rat plasma levels of approximately 650 pg/mL). An observational retrospective epidemiological cohort study utilising electronic health records from the United Kingdom was conducted to evaluate the risk of major congenital malformations following first trimester exposure to inhaled fluticasone propionate alone and salmeterol- fluticasone propionate combination relative to non- fluticasone propionate containing inhaled corticosteroids. No placebo comparator was included in this study. Toxicology has shown only those class effects typical of potent corticosteroids, and these only at doses greatly in excess of that proposed for therapeutic use. No novel effects were identified in repeat dose toxicity tests, reproductive studies or teratology studies. Fluticasone propionate is devoid of mutagenic activity in vitro and in vivo and showed no tumorigenic potential in rodents. It is both non-irritant and non-sensitising in animal models.