Joined in 2023 
82 
63 About this deal
Preparation of ρDAB (2 × 10 –3mol/l) solution by dissolving 29.8mg in 100mL of methanol with good shaking, was freshly prepared. Freeman, M. K. Efficacy and safety of linagliptin (tradjenta) in adults with type-2 diabetes mellitus. J Clin Pharm Ther. 36(12), 807 (2011). Widely Compatibility: TEGELI PD 20W USB C Charger plug is compatible with iPhone 14/13/13 pro/13 pro max /iPhone 12 / 12 Pro / 12 Pro Max / 12 Mini / 11/11 Pro / 11 Pro Max / 11 Mini / 10/10 Max / iPhone 8 / iPhone 7 / iPhone 7 plus / iPhone 6s / iPhone 6, Samsung Galaxy S21 / Galaxy S21 + / Galaxy S21 ultra / Galaxy S20 / Galaxy S10 / Galaxy S9 / Galaxy S8 / Note / Tab / A series. Sri, K. V., Anusha, M. & Reddy, S. R. A rapid RP-HPLC method development and validation for the analysis of linagliptinin bulk and pharmaceutical dosage form. Asian J. Pharm. Anal. 5(1), 16–20 (2015). Preparation of Linagliptin Standard Solution (2 × 10 –3mol/l) by weighted 94.5mg of LNG in 100mL of distilled water.
The quantitative reaction rate was recorded by Job’s Method of Continuous Variations and the Molar ratio method 14. Scientific, research, navigation, surveying, photographic, cinematographic, audiovisual, optical, weighing, measuring, signalling, detecting, testing, inspecting, life-saving and teaching apparatus and instruments; This research was approved by the Damascus University Faculty of Pharmacy deanship. Ethics approval and consent to participate
Linagliptin isn’t available as a specific method for analyzing in British pharmacopeia (BP) or the United States Pharmacopeia (USP). The Review of Research Literature has shown several articles for the determination of LNG in pharmaceutical forms, including the spectrophotometer in UV 3, 4, 5, also in VIS with chemical derivation using NQS (1,2-naphtho quinine 4-sulphonic acid sodium salt), vanillin 6 and picric acid 7 as a chromogenic reagents. Capillary Electrophoresis (CE) 8, and with high-performance liquid chromatography (HPLC) 9, 10, 11, 12, 13. Those methods are specificity and selectivity but they need more time, a lot of amount an expensive solvent and equipments. The TEGELI trademark was assigned an Application Number # UK00003730999 by the UK Intellectual Property Office (UKIPO). Linagliptin is a new oral antidiabetic agent. LNG isn’t available a specific analytical method in pharmacopeia. LNG has many articles that aim to assay LNG by HPLC, this method needs expensive solvents and specific equipments. So, this paper was described a new, simple analytical method depending in condensation reaction between LNG with PDAB as a chemical reagent for determination LNG in bulk and pharmaceutical dosage. The conditions of optimal conditions of this analytical research were studied and it was found that distilled water and methanol were the best solvents for both LNG and PDAB, 1mL of PDAB 5% as a derivative reagent with 2mL of HCl 37% as an acidic medium with heating to 70–75°C on a water bath for 35min to form the yellow Schiff base with a wavelength at 407nm and the stability of Schiff base formed for one hour. Validation of the proposed method was showed that this reaction has linearity 5–45μg/mL, according to the correlation coefficient R 2 = 0.9989 with percent recovery (99.46–100.8%) within an accepted criteria and RSD was less than 2%, so this proposed method has good accuracy and precision and high specificity. Furthermore, the molar ratio of this reaction was selected between LNG and PDAB it was (1:1) complex depending on two methods the Job of continuous variations and molar ratio. Sample was prepared by mixing mannitol 20mg, maize starch 30mg, pregelatinized starch 30mg, copovidone 5mg and magnesium stearate 4mg 16. These excipients were analyzed by proposed method. The results were referred good recovery 101.157% and RSD = 0.8387%. These means no interference between excipients and determination of LNG in pharmaceutical dosage by this derivative method. Robustness
Mourad, S. S., El-Kimary, E. I., Hamdy, D. A. & Barary, M. A. Stability-indicating HPLC-DAD method for the determination of linagliptin in tablet dosage form: Application to degradation kinetics. J Chromatogr. Sci. 54(9), 1560–1566 (2016). Rajbangshi, J. C., Alam, M. M., Hossain, M. S., Islam, M. S. & Rouf, A. S. S. Development and validation of a RP-HPLC method for quantitative analysis of linagliptin in bulk and dosage forms. Dhaka Univ. J. Pharm. Sci. 17(2), 175–182 (2018). diving suits, divers’ masks, ear plugs for divers, nose clips for divers and swimmers, gloves for divers, breathing apparatus for underwater swimming; Aliquots volume of working solution LNG were moved into series of 10mL volumetric flasks to perform final concentrations of 5–45ppm. To each flask was added 1mL of ρDAB 5% (w/v) and 2mL of HCl 37%, then to the water bath at 70–75° for 35min after closed and shaking very well, after those flasks were cooled and diluted to 10mL by distilled water. The maximum absorption of the yellow color was 407nm upon the blank. The amount of linagliptin was calculated from the calibration curve.Safe & Reliable: This type c charger is designed with double insulation protection and passed UKCA/CE Safety certified tests, safe to use and protect your device against over-voltage, over-current, over-heating, short-circuiting issues and ensures a safer and more stable charging for your usb-c device. Dalal, A., Tegeli, V. & Waghmode, R. Development and validation of a simple and rapid UV spectrophotometeric method for linagliptin in bulk and marketed dosage form. Der. Pharma Chem. 14(2), 23–26 (2022). The researcher studied the suitable of PDAB volume in the range of 0.5–3mL, to find the suitable volume of PDAB reagent (5% w/v). So, the result had shown that the highest absorption intensity was achieved at a PDAB volume of 1mL then it decreased (Fig. 3b). Evaluation of HCl volume Linagliptin—PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Linagliptin#section=Structures, Accessed 19 Jan 2022.
Baink, S., Kaisar, M. M. & Hossain, M. S. Development and validation of a simple and rapid UV spectrophotometer method for assay of linagliptin in bulk and marketed dosage form. Indian J. Nov. Drug. Deliv. 5(4), 221–224 (2013). Badugu, L. R. A validated RP-HPLC method for the determination of linagliptin. Am. J. Pharm. Tech. Res. 2(4), 463–470 (2012). Fda, Cder, Beers, Donald. Analytical Procedures and Methods Validation for Drugs and Biologics Guidance for Industry (2015). Chemical and Physical Properties of LNG: color and form: slightly hygroscopic, white to yellow solid. Melting Point: 190–195°C. Solubility: In water, 3.33mg/L at 25°C; soluble in methanol; sparingly soluble in ethanol. Stability: It is stable if stored as directed; avoid strong oxidizing agents 2.Durga Anumolu, P. et al. Quantification of linagliptin by chemical derivatization with appliance of chromogenic. J. Appl. Chem. Res. 11(2), 39–50 (2017). apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling the distribution or use of electricity; Sri, K. V. V., Anusha, A. & Sudhakar, M. UV-spectrophotometry method for the estimation of linagliptin in bulk and pharmaceutical formulations. Asian J. Res. Chem. 9(1), 47 (2016). w/v): 1.25 g was dissolved in 25 mL of methanol with good shaking, and was freshly prepared. Analytical procedure
Related:
Great Deal 
New Comment