Joined in 2023 
82 
63 About this deal
Our Molecule Scent 01 contains a proprietary mixture of Iso E Super, that focuses on gamma isomers, which results in increased allure. a b US 3929677,Hall, John B.&Sanders, James Milton,"Perfume composition and perfume articles containing one isomer of an octahydrotetramethyl acetonaphthone",issued 1975 OTNE has been recommended for inclusion in an update for the EU Fragrance Allergens labelling for cosmetic products based on a small number of positive reactions in dermatological clinics of around 0.2% to 1.7% of patients tested in three studies [18] a b Bonnie L. Carson (2001), "1-(1,2,3,4,5,6,7,8-Octahydro-2,3-8,8-tetramethyl-2-naphthalenyl) ethanone", Review of Toxicological Literature (PDF), National Institute of Environmental Health Sciences
Iso E Super, an aroma-chemical with its own distinct nature, goes beyond being a traditional fragrance and creates a captivating effect. With its almost transparent color, it exudes a subtle and elusive sweet cedarwood-like scent, evoking a masculine, woodsy, and musky aroma. It has earned the reputation of being the invisible fragrance and has been likened to the modern-day Love Potion No.9. The reason behind this is its unique ability to mimic the action of human pheromones. While not a pheromone itself, Iso E Super has the remarkable effect of catching the attention of others, who find themselves unable to pinpoint the exact reason for their intrigue. It creates an air of mystery that leaves people fascinated but unable to articulate why. The measured Bio Concentration Factor (BCF) is 391L/kg, which is well below the EU limit of 2000 and US limit of 1000 for Bioaccumulation (B) classification. The LogKow for OTNE has been measured to be 5.65. [7] standards library - IFRA International Fragrance Association - in every sense". www.ifraorg.org. Archived from the original on 2015-02-25. OTNE is the abbreviation for the fragrance material with Chemical Abstract Service ( CAS) numbers 68155-66-8, 54464-57-2 and 68155-67-9 and EC List number 915-730-3. It is a multi-constituent isomer mixture containing:The distinction of Iso E Super lies in its design as an aroma-chemical rather than a traditional fragrance. Ordinary fragrances are crafted to project themselves over a wide radius, while Iso E Super is specifically formulated to cling to the skin, effortlessly oscillating between moments of opulence and simplicity. This duality allows it to be at times distinctly noticeable and at other times undetectable, creating an intriguing and ever-changing olfactory experience. The wearer may perceive a subtle, velvety, and woody note that momentarily fades away, only to resurface after some time, enhancing the fragrance's allure and complexity. The biodegradation of OTNE in fresh water (T1/2) is at most 40 days, and at most 120 days in sediment (OECD 314 test), though the biodegradation within the 28day window was around 11% (OECD 301-C). Given the outcome of the OECD 314 test OTNE does not meet the criteria for “Persistent” (P) or “very Persistent” (vP). Scientific Committee on Consumer Safety (2011). "Annex I: Clinical evidence regarding sensitisation to individual fragrance chemicals and to natural extracts" (PDF). SCCS Opinion on fragrance allergens in cosmetics. European Union. p.63. SCCS/1459/11.
Carrying out the initial Diels–Alder reaction using a Lewis acid catalyst such as aluminum chloride appears to ensure that the acetyl group is at position 2 of the resulting cyclohexene adduct, which distinguished Iso E Super from other (previously patented) fragrances based on tetramethylacetyloctaline. The second cyclization reaction yields a mixture of diastereomers with the general structure depicted above, the predominant ones being (2 R,3 R) and (2S,3S). [1] Chemical Summary [ edit ] OTNE has been detected in surface water at levels of 29–180ng/L, [15] [16] These values are well below the Predicted No Effect Concentration (PNEC) and as a result the overall environmental risk ratio (also referred to as RCR or PEC/PNECS) is determined to be below 1. [7] Regulatory status [ edit ] Iso E Super may cause allergic reactions detectable by patch tests in humans [8] and chronic exposure to Iso E Super from perfumes may result in permanent hypersensitivity. In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but negative in the mouse ear swelling test (MEST). [9] Several health related studies have been conducted on OTNE, and based on these studies, OTNE has been determined to be safe under the current conditions of use. [12] [13] The fragrance Eternity by Calvin Klein (1988) contained 11.7% Iso E Super in the fragrance portion of the formula.
Klashka; etal. (2013). "Occurrences and potential risks of 16 fragrances in five German sewage treatment plants and their receiving waters". Environ. Sci. Pollut. Res. 20 (4): 2456–71. doi: 10.1007/s11356-012-1120-9. PMID 22945655. S2CID 31312476. Beyond personal perception, the impact of Iso E Super on others is truly remarkable. It lends an indefinable allure to the wearer, captivating those who encounter its aroma. Its effect is reminiscent of pheromones, drawing attention and fascination without a clear explanation. No data were available regarding chemical disposition, metabolism, or toxicokinetics; acute, short-term, subchronic, or chronic toxicity; synergistic or antagonistic activity; reproductive or teratological effects; carcinogenicity; genotoxicity; or immunotoxicity. [5]
Great Deal 
New Comment