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Gonge G-2117 Tactile Discs, Multicolour

£41.495£82.99Clearance
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Ikeda R, Cha M, Ling J, Jia Z, Coyle D, Gu JG (2014) Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses. Cell 157:664–675 Cahusac PM, Senok SS (2006) Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors. Synapse 59:235–242 Encourage children to shake the discs to light them up, allowing them to experiment with cause and effect. The textured design provides an additional sensory appeal, while the tactile properties allow children to grip and manipulate the discs. Suitable for 10 months and up. Maricich SM, Wellnitz SA, Nelson AM, Lesniak DR, Gerling GJ et al (2009) Merkel cells are essential for light-touch responses. Science 324:1580–1582 The mat encourages you to work your toes. In fact, I almost can ’t help it. I find my toes naturally trying to grip the different textures as I walk.

Carvell GE, Simons DJ (1990) Biometric analyses of vibrissal tactile discrimination in the rat. J Neurosci 10:2638–2648 Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S et al (2010) Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330:55–60Johansson RS, Flanagan JR (2009) Coding and use of tactile signals from the fingertips in object manipulation tasks. Nat Rev Neurosci 10:345–359

Ikeda I, Yamashita Y, Ono T, Ogawa H (1994) Selective phototoxic destruction of rat Merkel cells abolishes responses of slowly adapting type I mechanoreceptor units. J Physiol 479(Pt 2):247–256 Maksimovic S, Baba Y, Lumpkin EA (2013) Neurotransmitters and synaptic components in the Merkel cell-neurite complex, a gentle-touch receptor. Ann N Y Acad Sci 1279:13–21 Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH et al (2003) Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 13:4477–4480 WHAT YOU GET (SIZE/DIMENSIONS/COLORS): 6 Tactile Sensory Discs each approximately 5 inches ibn diameter featuring calming textures soft mop, flip-sequins, squishy sponge, colorful sand, colorful beads with hidden letters, and colorful balls with hidden shapes. Diamond J, Holmes M, Nurse CA (1986) Are Merkel cell-neurite reciprocal synapses involved in the initiation of tactile responses in salamander skin? J Physiol 376:101–120Tofthagen C, McAllister RD, Visovsky C (2013) Peripheral neuropathy caused by Paclitaxel and docetaxel: an evaluation and comparison of symptoms. J Adv Pract Oncol 4:204–215 Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J et al (2000) The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407:1007–1011

Albers J, Chaudhry V, Cavaletti G, Donehower R (2007) Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database Syst Rev 24:CD005228 Driscoll M, Chalfie M (1991) The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature 349:588–593

Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL et al (2014) Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509:617–621

TARGETED SKILLS: Students can build fine motor skills in their fingers and hands as they press, pinch, fidget, and squeeze. These actions help build up the small muscles in the hand – the same muscles used when holding a crayon, marker, or pencil! Halata Z, Grim M, Bauman KI (2003) Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol 271:225–239 Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS et al (2007) Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer 110:2110–2118 Ebara S, Kumamoto K, Matsuura T, Mazurkiewicz JE, Rice FL (2002) Similarities and differences in the innervation of mystacial vibrissal follicle-sinus complexes in the rat and cat: a confocal microscopic study. J Comp Neurol 449:103–119

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Diamond ME, von Heimendahl M, Knutsen PM, Kleinfeld D, Ahissar E (2008) ‘Where’ and ‘what’ in the whisker sensorimotor system. Nat Rev Neurosci 9:601–612 Kautio AL, Haanpaa M, Kautiainen H, Kalso E, Saarto T (2011) Burden of chemotherapy-induced neuropathy – a cross-sectional study. Support Care Cancer 19:1991–1996 Senok SS, Baumann KI, Halata Z (1996) Selective phototoxic destruction of quinacrine-loaded Merkel cells is neither selective nor complete. Exp Brain Res 110:325–334

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