Healthspan Vein Vine 360mg (90 Tablets) | for Tired & Heavy Legs | Maintains Healthy Leg-Vein Functions | Red Vine Leaf Extract | Added Vitamins B1 & C | Vegan

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Nees et al (2003) undertook an in vitro study to increase understanding of the effects of endothelial inhibitors and to explore the possible role of venular endothelial cells in the development of connective tissue failure characteristically seen in CVI. It was discovered that a standardised extract of red vine leaves (AS 195) not only protected venular endothelial cells but also, when applied to previously damaged cells, could prompt cellular repair. The treatment is provided with advanced protocols based on the Physics of radiofrequency and ultrasound and on the anatomy and physiology of cellulite and skin laxity The usual dose is 360 mg to 720 mg daily, but follow manufacturer’s instructions as the concentration of red vine leaf extracts vary. Only select supplements made to a pharmaceutical standard known as GMP, as low quality red vine leaf products (on sale in health food shops in Japan) were found to contain low levels of active polyphenols, and inconsistent levels per tablet. Several natural supplements are used for CVI which can help relieve symptoms of the condition, including centella asiatica/gotu kola extract, hesperidin, diosmin, butcher’s broom extract, escin/horse chestnut extract and red vine leaf extract among others. The LipoTherapeia® treatment is exclusively provided at our practice in Marylebone, London (The Light Centre, Clearwater Court, 49 Marylebone High Street, London, W1U 5HJ)

Leach, M.J. (2004) Making sense of the venous leg ulcer debate: a literature review. Journal of Wound Care; 13: 4, 52-56. Kiesewetter et al’s (2000) randomised double-blind placebo-controlled parallel group multicentre study aimed to assess the efficacy of AS 195 in treating symptoms of CVI. Success was measured in terms of limb volume and ankle and calf circumference reduction, as well as by subjective questioning of the trial subjects about their symptoms. Patients were recruited into one of three study arms: 360mg red vine leaf extract AS 195 per day; 720mg red vine leaf extract AS 195 per day; or placebo. Food Supplements are intended to supplement the diet and should not be substituted for a varied diet or healthy lifestyle. Not suitable for children under 12. Before taking this product please consult your doctor of pharmacist if you are taking any medication or are pregnant, breastfeeding or trying to become pregnant.Vine leaf extract might sound like a weird remedy for CVI. However, it is more effective than it sounds. It is extracted from grapevines and can be considered the cousin of red wine. You might be aware of the incredible benefits of red wines due to their resveratrol property. The wine is not the only nutritious and healing part of the vine. The leaves are also considered a good source of the most powerful and fully natural compound to come out of a vine. There are various medical procedures to close or remove varicose veins. This does not cause problems because there are enough other veins to carry the blood flow.

In addition, red vine leaf extract improved skin microcirculation and transcutaneous oxygen pressure - ideal for cellulite prevention and reduction. The phytonutrients present in its leaves act as natural venotonics, angioprotectors and anti-edematous. In other words, they contribute to the tonicity and protection of blood vessels and capillaries. They are particularly capable of reducing the permeability of blood vessels and improving their resistance. Therefore, a red vine treatment may be of interest to combat venous insufficiency, to alleviate the sensation of heavy and / or swollen legs, among other benefits. So if you suffer from CVI, water retention and cellulite, it would be a good idea to consult with a qualified healthcare practitioner regarding the use of red vine leaf extract (as well as centella asiatica/gotu kola extract, hesperidin, diosmin, butcher’s broom extract and escin/horse chestnut extract, among others). A source of flavonoids that has undergone extensive preclinical and clinical investigation is the red vine leaf extract AS 195. This has shown that its flavonoids may have significant benefits for patients with pre-ulcer venous hypertension. Red vine leaf extract AS 195Kiesewetter, H. et al (2000) Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). Arzneimittelforschung; 50: 2, 109-117. Hollman, P.C., Katan, M.B. (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomedical Pharmacotherapy; 51: 8, 305-310. The study lasted for 12 weeks and at the end of that duration, those who were using the red vine leaf extract recorded remarkable improvements in their conditions. The accelerated rate of blood flow from the legs resulted in a drastic reduction in the volumes and circumference of the legs. Kalus et al’s (2004) study was designed to identify the improvement of cutaneous microcirculation and oxygen supply. This double-blind randomised placebo-control crossover trial involved 71 patients with cutaneous microcirculation. Group one (n=36) received red vine leaf extract AS 195 360mg daily for six weeks followed by a four-week washout (break between treatments) and six-week placebo treatment. Group two (n=35) received placebo, then washout, then red vine leaf extract AS 195 360mg daily for six weeks. After six weeks of treatment, the intervention group had an increase in microvascular bloodflow values compared with a decrease in the placebo group. Transcutaneous oxygen increased in the intervention group, while in the placebo group it decreased. Leg circumference decreased in the intervention group compared with the placebo group. Evaluating the evidence One of the first studies to assess the effectiveness of red vine leaf extracts (Antistax) asked 71 people with leg swelling (due to chronic venous insufficiency) to take 360mg red vine leaf extracts, or placebo during two separate periods of 6 weeks. This meant that each person tried both treatments and acted as their own controls.

According to research, red vine leaves owe all of their health effect to their antioxidant content. Antioxidants found in red vine leaves include flavonoids (quercetin-3-O-beta-D-glucuronide, isoquercetin, myricetin, kaempferol), catechins, epicatechins, anthocyanins, procyanidins and proanthocyanidins. Other famous antioxidant compounds in the leaves include resveratrol, also found in grapes and grape wine, and viniferin, the main bioactive constituent in grapevine sap. ( Phytopharmacy: An evidence-based guide to herbal medicinal products). The researchers concluded that adding angioprotectors ( red vine leaf extract) to standard medical treatment helps to correct endothelial dysfunction (the ability of veins to recover and dilate) and may improve the immediate results for patients with acute venous thrombosis. Red vine leaf dose This study showed a marked improvement in patients under treatment, both subjectively in terms of symptoms and objectively in limb measurements. Those receiving the higher-dose preparation experienced a slightly greater effect, and this was sustained for a longer period after the trial had been discontinued. According to those studies, oral intake of red vine leaf extract significantly improved all the above clinical outcomes, namely lower leg volume, calf and ankle circumference, tired/heavy legs, tingling sensation, pain, tension sensation in the legs. Prices and special offers: Subject to change without prior notice. Special offers can not be combined.

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Chronic venous insufficiency (CVI) is mainly caused by venous and capillary hypertension and this leads to a persistent, chronic, venous stasis in the skin of the lower leg. Typical CVI complaints, such as tired, heavy and swollen legs, and tension and pain in the legs, are the warning signs of a progressive, chronic condition.